A major SSRC project of the past decade, Producing Knowledge on World Regions, has taken an in-depth look at the configuration of regional studies and internationalization in higher education. One component of the project focused specifically on the Middle East, and here program director Seteney Shami and Cynthia Miller-Idriss draw attention to key transformations and continuities in Middle East studies and how they relate to both regional dynamics and American perceptions and policies.