The Social Science Research Council recently launched a series of new Agenda Fund initiatives focused on accelerating public innovation, or the discovery and implementation of more effective ways of delivering public goods and services like health, education, safety, clean air and water, growth-oriented infrastructure, and scientific and technological innovation. In this President’s Desk essay, SSRC President Anna Harvey reflects on how emerging research on the determinants of innovation in governments and universities can help us design, test, and implement evidence-based strategies that accelerate public innovation.